The Power of Polynucleotides in Skin Regeneration
Plinest is an innovative skin regeneration treatment powered by PN-HPT® polynucleotides (derived from Italian Trout DNA), clinically proven to repair, regenerate, and deeply hydrate the skin. Unlike traditional injectables, Plinest works at a cellular level to improve tissue quality, boost collagen, and enhance healing, making it especially effective for fragile, aging, or damaged skin.
It is particularly beneficial for aged skin, addressing the specific needs associated with skin aging by restoring elasticity, reducing wrinkles, and enhancing overall skin appearance. Plinest also contributes to skin tissue regeneration by supporting the restoration of normal skin function and appearance after injury or environmental damage.
At Hebe Clinic, Plinest is used to restore skin vitality in a natural and biocompatible way. It is suitable for individuals seeking both aesthetic improvement and long term skin health repair. Plinest helps improve skin health by supporting the skin’s natural renewal processes, enhancing elasticity, and reducing visible signs of aging.
The Power of Polynucleotides in Skin Regeneration
Plinest is an innovative skin regeneration treatment powered by PN-HPT® polynucleotides (derived from Italian Trout DNA), clinically proven to repair, regenerate, and deeply hydrate the skin. Unlike traditional injectables, Plinest works at a cellular level to improve tissue quality, boost collagen, and enhance healing, making it especially effective for fragile, aging, or damaged skin.
It is particularly beneficial for aged skin, addressing the specific needs associated with skin aging by restoring elasticity, reducing wrinkles, and enhancing overall skin appearance. Plinest also contributes to skin tissue regeneration by supporting the restoration of normal skin function and appearance after injury or environmental damage.
At Hebe Clinic, Plinest is used to restore skin vitality in a natural and biocompatible way. It is suitable for individuals seeking both aesthetic improvement and long term skin health repair. Plinest helps improve skin health by supporting the skin’s natural renewal processes, enhancing elasticity, and reducing visible signs of aging.
How it works on Skin Cells
Plinest supports skin regeneration by interacting directly with human skin at the cellular level. Its high-purity polynucleotides help activate the regeneration process through multiple biological pathways.
Plinest delivers high-purity polynucleotides that:
● Stimulate fibroblasts and support cell proliferation → boosting collagen and elastin production by encouraging the growth and division of skin cells
● Promote tissue regeneration → improving skin structure and elasticity through the involvement of growth factors such as epidermal growth factor and fibroblast growth factor, which are key in tissue repair and collagen synthesis
● Mimic the effects of topical growth factors → stimulating collagen production and promoting skin regeneration, similar to advanced skin rejuvenation treatments
● Enhance hydration → restoring softness and suppleness
● Reduce inflammation & oxidative stress → helping repair and protect skin from damage by protecting skin cells from cell cycle arrest, which can be triggered by aging or environmental stress
● Activate the body's natural healing process → similar to PRP and MSC-derived Cell Therapy, Plinest helps initiate tissue repair and skin rejuvenation
This mechanism makes Plinest effective for improving skin quality, enhancing overall skin texture, and supporting long-term skin rejuvenation without relying on volume-based fillers.
How it works on Skin Cells
Plinest supports skin regeneration by interacting directly with human skin at the cellular level. Its high-purity polynucleotides help activate the regeneration process through multiple biological pathways.
Plinest delivers high-purity polynucleotides that:
● Stimulate fibroblasts and support cell proliferation → boosting collagen and elastin production by encouraging the growth and division of skin cells
● Promote tissue regeneration → improving skin structure and elasticity through the involvement of growth factors such as epidermal growth factor and fibroblast growth factor, which are key in tissue repair and collagen synthesis
● Mimic the effects of topical growth factors → stimulating collagen production and promoting skin regeneration, similar to advanced skin rejuvenation treatments
● Enhance hydration → restoring softness and suppleness
● Reduce inflammation & oxidative stress → helping repair and protect skin from damage by protecting skin cells from cell cycle arrest, which can be triggered by aging or environmental stress
● Activate the body's natural healing process → similar to PRP and MSC-derived Cell Therapy, Plinest helps initiate tissue repair and skin rejuvenation
This mechanism makes Plinest effective for improving skin quality, enhancing overall skin texture, and supporting long-term skin rejuvenation without relying on volume-based fillers.
Who is it suitable for?
Plinest is recommended for individuals with:
● Aging or thinning skin that has lost elasticity
● Fine lines and wrinkles
● Sagging skin
● Fragile or damaged skin (post-acne, post-laser, scars)
● Active acne or post-acne skin (helps calm inflammation and repair tissue)
● Inflammation-prone skin including redness or sensitivity
● Dry, dull, or uneven texture
● Acne Scars
● Preventive care for those wanting to slow down skin aging
Plinest supports the regeneration of not only the dermis but also the subcutaneous tissue, which is important for overall skin structure and resilience. For severe tissue loss or wounds, bioengineered skin substitutes may be used alongside regenerative treatments like Plinest to promote tissue regeneration.
Who is it suitable for?
Plinest is recommended for individuals with:
● Aging or thinning skin that has lost elasticity
● Fine lines and wrinkles
● Sagging skin
● Fragile or damaged skin (post-acne, post-laser, scars)
● Active acne or post-acne skin (helps calm inflammation and repair tissue)
● Inflammation-prone skin including redness or sensitivity
● Dry, dull, or uneven texture
● Acne Scars
● Preventive care for those wanting to slow down skin aging
Plinest supports the regeneration of not only the dermis but also the subcutaneous tissue, which is important for overall skin structure and resilience. For severe tissue loss or wounds, bioengineered skin substitutes may be used alongside regenerative treatments like Plinest to promote tissue regeneration.
Key Benefits: Improve Skin Texture
● Tissue Repair & Healing – accelerates recovery from damage and scarring by supporting both skin repair and skin healing. Skin repair refers to the ongoing healing of existing tissue, while skin regeneration involves the complete replacement of damaged tissue with new tissue.
● Improved Skin Regeneration – Plinest can improve skin regeneration, leading to more complete restoration of skin structure and function.
● Skin Wound Healing – promotes faster skin wound healing by enhancing tissue repair and regeneration, making it effective for wounds and damaged skin.
● Improved Elasticity – firmer, more resilient skin
● Anti-Inflammatory Action – calms redness, acne, and oxidative stress
● Safe & Biocompatible – gentle even for sensitive or compromised skin
Key Benefits: Improve Skin Texture
● Tissue Repair & Healing – accelerates recovery from damage and scarring by supporting both skin repair and skin healing. Skin repair refers to the ongoing healing of existing tissue, while skin regeneration involves the complete replacement of damaged tissue with new tissue.
● Improved Skin Regeneration – Plinest can improve skin regeneration, leading to more complete restoration of skin structure and function.
● Skin Wound Healing – promotes faster skin wound healing by enhancing tissue repair and regeneration, making it effective for wounds and damaged skin.
● Improved Elasticity – firmer, more resilient skin
● Anti-Inflammatory Action – calms redness, acne, and oxidative stress
● Safe & Biocompatible – gentle even for sensitive or compromised skin
Treatment Experience
● Duration: 30–40 minutes
● Downtime: Minimal — mild redness, swelling, or bruising may occur and usually resolves within a few days
● Comfort: Tolerated well with numbing cream
● Frequency: Initial course of 4 sessions, spaced 4 weeks apart, then maintenance every 6–12 months
✨ At Hebe Clinic, Plinest offers science-backed regeneration and hydration, giving your skin not just beauty, but restored strength and vitality. Plinest can also be combined with other advanced skin treatments, such as skin boosters or poly-L-lactic acid fillers, for enhanced results. ® Skin Regeneration Therapy with professional techniques to help you achieve healthier, firmer, and more radiant skin — safely and naturally.
Treatment Experience
● Duration: 30–40 minutes
● Downtime: Minimal — mild redness, swelling, or bruising may occur and usually resolves within a few days
● Comfort: Tolerated well with numbing cream
● Frequency: Initial course of 4 sessions, spaced 4 weeks apart, then maintenance every 6–12 months
✨ At Hebe Clinic, Plinest offers science-backed regeneration and hydration, giving your skin not just beauty, but restored strength and vitality. Plinest can also be combined with other advanced skin treatments, such as skin boosters or poly-L-lactic acid fillers, for enhanced results. ® Skin Regeneration Therapy with professional techniques to help you achieve healthier, firmer, and more radiant skin — safely and naturally.
Aftercare and Maintenance
After treatment, patients are advised to:
Avoid direct sun exposure and use broad-spectrum sunscreen to protect skin structure
Keep skin hydrated to support collagen production and skin elasticity
Maintain a consistent skin care routine focused on skin repair and barrier support
Use antioxidants such as vitamin C to improve skin tone and protect against sun exposure
Avoid harsh products that may compromise sensitive skin during healing
Advanced regenerative approaches such as stem cell therapy, adipose derived stem cells, or platelet rich plasma may be considered separately where clinically appropriate. Ongoing stem cell research continues to explore how pluripotent stem cells and induced pluripotent stem cells may further support tissue regeneration and skin wound healing in the future.
Aftercare and Maintenance
After treatment, patients are advised to:
Avoid direct sun exposure and use broad-spectrum sunscreen to protect skin structure
Keep skin hydrated to support collagen production and skin elasticity
Maintain a consistent skin care routine focused on skin repair and barrier support
Use antioxidants such as vitamin C to improve skin tone and protect against sun exposure
Avoid harsh products that may compromise sensitive skin during healing
Advanced regenerative approaches such as stem cell therapy, adipose derived stem cells, or platelet rich plasma may be considered separately where clinically appropriate. Ongoing stem cell research continues to explore how pluripotent stem cells and induced pluripotent stem cells may further support tissue regeneration and skin wound healing in the future.
Frequently Asked Questions
Frequently Asked Questions
Frequently Asked Questions
How Is Plinest Different Compared to Dermal Fillers?
Plinest focuses on skin regeneration rather than volume replacement. While dermal fillers restore shape or contour, Plinest supports collagen production, tissue repair, and skin quality at a cellular level.
Can Chanel NCTF® 135 HA be used alongside an existing skincare routine?
Yes. It is often chosen to complement topical skincare by supporting skin quality at a deeper, cellular level.
Is Plinest suitable for sensitive skin?
Yes. Plinest is known for its high biocompatibility and is generally well tolerated, even in individuals with sensitive or inflammation prone skin. It is often chosen for patients whose skin may not respond well to more aggressive treatments such as strong lasers or certain fillers. A consultation is still required to assess individual skin conditions.
Is Chanel NCTF® 135 HA suitable if my main concern is dull skin rather than aging?
Yes. This treatment is commonly chosen for dull or tired-looking skin, even when visible aging is not the primary concern.
Is Chanel NCTF® 135 HA suitable if my main concern is dull skin rather than aging?
No. It is not designed to add volume or alter facial contours. The goal is improved hydration and skin firmness, not fullness.
How soon can I see results after Plinest treatment?
Some patients notice improved hydration and skin texture within a few weeks. More visible improvements such as better elasticity, smoother skin, and overall skin health typically develop gradually as collagen production and tissue regeneration increase. Results tend to improve with each session and continue over time.
Does this treatment cause visible volume changes in the face?
No. Chanel NCTF® 135 HA focuses on skin quality and vitality rather than adding volume or altering facial contours.
How long do the results last?
Results vary depending on skin condition, age, and lifestyle factors such as sun exposure and skincare habits. After completing the initial treatment course, improvements can last several months. Maintenance sessions every six to twelve months are commonly recommended to support ongoing skin regeneration.
Is this treatment appropriate for patients who want results without dramatic change?
Yes. Improvements develop gradually, making it suitable for those who prefer subtle enhancement over immediate transformation.
Can Plinest be combined with other aesthetic treatments?
Yes. Plinest is often combined with other treatments such as skin boosters, dermal fillers, laser treatments, or chemical peels depending on individual skin goals. Combination treatments are usually planned carefully to avoid over treatment and to support optimal skin healing.
Can Chanel NCTF® 135 HA be used during seasonal skin changes?
It is often considered when skin becomes dehydrated or stressed due to environmental or seasonal factors.
Who should avoid Plinest treatment?
Plinest may not be suitable for individuals who are pregnant, breastfeeding, or have active skin infections at the treatment site. Those with certain medical conditions should disclose their health history during consultation so suitability can be assessed safely.
Who may not be suitable for this treatment?
Patients with certain skin conditions, active infections, or specific medical considerations should undergo assessment before treatment.
Stay Inspired
Book your consultation now
We offer personalized aesthetic and wellness treatments to help everyone feel confident at every age.
Stay Inspired
Book your consultation now
We offer personalized aesthetic and wellness treatments to help everyone feel confident at every age.
Location
Level 2, Wisma TJB Bangsar, No.2 Jalan Telawi 1, Bangsar Baru 59100, Kuala Lumpur.
Opening Hours
Monday:
10:00 AM – 7:00 PM
Tuesday:
10:00 AM – 7:00 PM
Wednesday:
10:00 AM – 7:00 PM
Thursday:
10:00 AM – 7:00 PM
Friday:
10:00 AM – 7:00 PM
Saturday:
9:00 AM – 6:00 PM
Sunday:
9:00 AM – 6:00 PM
Location
Level 2, Wisma TJB Bangsar, No.2 Jalan Telawi 1, Bangsar Baru 59100, Kuala Lumpur.
Opening Hours
Monday:
10:00 AM – 7:00 PM
Tuesday:
10:00 AM – 7:00 PM
Wednesday:
10:00 AM – 7:00 PM
Thursday:
10:00 AM – 7:00 PM
Friday:
10:00 AM – 7:00 PM
Saturday:
9:00 AM – 6:00 PM
Sunday:
9:00 AM – 6:00 PM
Location
Level 2, Wisma TJB Bangsar, No.2 Jalan Telawi 1, Bangsar Baru 59100, Kuala Lumpur.
Opening Hours
Monday:
10:00 AM – 7:00 PM
Tuesday:
10:00 AM – 7:00 PM
Wednesday:
10:00 AM – 7:00 PM
Thursday:
10:00 AM – 7:00 PM
Friday:
10:00 AM – 7:00 PM
Saturday:
9:00 AM – 6:00 PM
Sunday:
9:00 AM – 6:00 PM